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聂舟

    

教授,博士生导师
Tel: 86-731-88821626
E-mail:
niezhou.hnu@gmail.com
研究方向:功能蛋白质和核酸的生物传感新方法研究





聂舟,男,博士,湖南大学化学化工学院教授,博士生导师。2002年本科毕业于南开大学生物化学与分子生物学系,获理学学士学位;2007年于中国科学院化学研究所获物理化学博士学位;2012年于美国Purdue大学从事博士后(公派)研究工作。主要研究方向为功能蛋白质和核酸的生物传感新方法研究。自2009年以来作为通讯作者在Angewandte Chemie International EditionChemical ScienceNucleic Acids ResearchTrends in Analytical ChemistryAnalytical ChemistrySmallChemical CommunicationsChemistry-A European JournalNanoscaleSCI收录源刊物上发表SCI论文50余篇(影响因子> 545篇),近五年论文他引1700余次,其中单篇最高他引120余次。获国家发明专利授权2项,受邀为Springer出版社撰写英文学术专著2章。5年内主持国家自然科学基金4项,省部级项目4项,参与973子课题2项。2016年入选教育部“长江学者”青年学者,并获得中国化学会青年化学奖;2015年入选中组部“万人计划”青年拔尖人才,并获得卢嘉锡优秀导师奖;2012年获得首届国家自然科学基金青年基金项目;是国家自然科学基金委创新研究群体基金项目的主要成员之一;此外还获得湖南省杰出青年基金支持,以及入选首届湖湘青年科技创新创业平台培养对象及教育部新世纪人才支持计划。20157月应邀出任英国皇家化学会所属学术期刊《RSC AdvancesAssociate Editor





Selected Publications:


1. Z.L. Liu, X.Y. Luo, Z. Li, Y. Huang, Z. Nie*, H.H. Wang*, S.Z. Yao. Enzyme-activated G-quadruplex synthesis for in situ label-free detection and bioimaging of cell apoptosis.Anal. Chem., 2017, 89, 1892-1899.


2. Y. Li, P. Li, R. Zhu, C. Luo, H. Li, S.F. Hu, Z. Nie*, Y. Huang, S.Z. Yao.Multifunctional gold nanoclusters-based nanosurface energy transfer probe for real-time monitoring of cell apoptosis and self-evaluating of pro-apoptotic theranostics. Anal. Chem., 2016, 88, 11184-11192.


3. W. Li, Y. Li, Z.L. Liu, B. Lin, H.B. Yi, F. Xu, Z. Nie*, S.Z. Yao. Insight into G-quadruplex-hemin DNAzyme/RNAzyme: adjacent adenine as the intramolecular species for remarkable enhancement of enzymatic activity. Nucleic Acids Res.,2016, 44, 7373-7384.


4. W. Li, Y. Li, K.Y. He, P. Li, Y. Huang, Z. Nie*, S.Z. Yao. A biomimetic colorimetric logic gate system based on multi-functional peptide-mediated gold nanoparticle assembly. Nanoscale, 2016, 8, 8591-8599.


5. X.H. Zhu, T.B. Zhao, Z. Nie*, Z. Miao, Y. Liu*, S.Z. Yao. Nitrogen-doped carbon nanoparticle modulated turn-on fluorescent probes for histidine detection and its imaging in living cells. Nanoscale, 2016, 8, 2205-2211.


6.K.Y. He, Y. Li, B.B. Xiang, P. Zhao, Y.F. Hu, Y. Huang, W. Li, Z. Nie*, S.Z. Yao. A universal platform for building molecular logic circuits based on a reconfigurable three-dimensional DNA nanostructure. Chem. Sci., 2015,6, 3556-3564.


7. Y.T. Han, P. Li, Y.T. Xu, H. Li, Z.L. Song, Z. Nie*, Z. Chen*, S.Z. Yao. Fluorescent nanosensor for probing histone acetyltransferase activity based on acetylation protection and magnetic graphitic nanocapsules, Small, 2015, 11, 877-885.


8. P. Zhao, K.Y. He, Y.T. Han, Z. Zhang, M.Z. Yu, H.H. Wang, Y. Huang, Z. Nie*, S.Z. Yao.Near-infrared dual-emission quantum dots-gold nanoclusters nanohybrid via co-template synthesis for ratiometric fluorescent detection and bioimaging of ascorbic acid in vitro and in vivo.Anal. Chem., 2015, 87, 9998-10005.


9. Y.T. Han, H. Li, Y.F.Hu, P. Li, H.X. Wang,Z. Nie*, S.Z. Yao.Time-resolved luminescence biosensor for continuous activity detection of protein acetylation-related enzymes based on DNA-sensitized terbium(III) probes. Anal. Chem., 2015, 87, 9179-9185.


10. C. Yin, M. Wang, C.Y. Lei, Z. Wang, P. Li, Y. Li, W. Li, Y. Huang*, Z. Nie*, S.Z. Yao.Phosphorylation-mediated assembly of a semisynthetic fluorescent protein for label-free detection of protein kinase activity.Anal. Chem., 2015, 87, 6311-6318.


11. S.Y. Chen, Y. Li, Y.F. Hu, Y.T. Han, Y. Huang,Z. Nie*, S.Z. Yao. Nucleic acid-mimicking coordinationpolymerforlabel-free fluorescent activity assay of Histone Acetyltransferases, Chem Commun., 2015, 51, 4469-4472.


12. Y.F. Hu, S.Y. Chen, Y.T. Han, H.J. Chen, Q. Wang, Z. Nie*, Y. Huang, S.Z. Yao.Unique electrocatalytic activity of a nucleic acid-mimicking coordination polymer for the sensitive detection of coenzyme A and histone acetyltransferase activity. Chem. Commun., 2015, 51, 17611-17614.


13. S. Tang, Z. Nie*, W. Li*, D.Q. Li, Y. Huang,S.Z. Yao.A poly(ADP-ribose) polymerase-1 activity assay based on the FRET between a cationic conjugated polymer and supercharged green fluorescent protein.Chem. Commun., 2015,51, 14389-14392.


14. Z. Wang,Y. Li, L.J. Li, D.Q. Li, Y. Huang*, Z. Nie*,S.Z. Yao.DNA-mediated supercharged fluorescent protein/graphene oxide interaction for label-free fluorescence assay of base excision repair enzyme activity. Chem. Commun., 2015,51, 13373-13376.


15.C.Y. Lei, Y. Huang, Z. Nie*, J. Hu, L.J. Li, G.Y. Lu, Y.T. Han, S.Z. Yao. Supercharged fluorescent protein as a versatile probe for homogenous DNA detection and methylation analysis. Angew. Chem. Int. Ed., 2014, 53, 8358-8362. (Hot Paper)


16.Z. Nie*, P.F. Wang, C. Tian, C.D. Mao*. Synchronization of two assembly processes to build responsive DNA nanostructures. Angew. Chem. Int. Ed., 2014, 53, 8402-8405.


17.X. Liu, Y. Li, X.H. Xu, P. Li, Z. Nie*, Y. Huang, S.Z. Yao*. Nanomaterial-based tools for protein kinase bioanalysis. Trends Anal. Chem., 2014, 58, 40-53.(Invited Review)


18.Z.L. Liu, W. Li, Z. Nie*, F.F. Peng, Y. Huang, S.Z. Yao. Randomly arrayed G-quadruplexes for label-free and real-time assay of enzyme activity. Chem. Commun., 2014, 50, 6875-6878.


19.J. Zhou, X.H. Xu, W. Liu, X. Liu, Z. Nie*, M. Qing, L.H. Nie, S.Z. Yao. Graphene oxide-peptide nanocomplex as a versatile fluorescence probe of protein kinase activity based on phosphorylation protection against carboxypeptidase digestion. Anal. Chem., 2013, 85, 5746-5754.


20.P. Zhao, L.F. Zhou, Z. Nie*, X.H. Xu, W. Li, Y. Huang, K.Y. He, S.Z. Yao. Versatile electrochemiluminescent biosensor for protein-nucleic acid interaction based on the unique quenching effect of deoxyguanosine-5’-phosphate on electrochemiluminescence of CdTe/ZnS quantum dots. Anal. Chem., 2013, 85, 6279-6286.


21.X. Liu, S.Y. Zhang, P.L. Tan, J. Zhou, Y. Huang, Z. Nie*, S.Z. Yao. A plasmonic blood glucose monitor based on enzymatic etching of gold nanorods. Chem. Commun., 2013, 49, 1856-1858.


22.Z. Nie, X. Li, Y.M. Li, C. Tian, P.F. Wang, C.D. Mao*, Self-assembly of DNA nanoprisms with only two component strands. Chem. Commun., 2013, 49, 2807-2809.


23.F.F. Li, C.Y. Lei, Q.P. Shen, L.J. Li, M. Wang, M.L. Guo, Y. Huang*, Z. Nie*, S.Z. Yao. Analysis of copper nanoparticles toxicity based on a stress-responsive bacterial biosensor array. Nanoscale, 2013, 5, 653-662.


24.X.H. Xu, J. Zhou, X. Liu, Z. Nie*, M. Qing, M.L. Guo, S.Z. Yao, Aptameric Peptide for One-Step Detection of Protein Kinase, Anal. Chem., 2012, 84, 4746-4753.


25.K.Y. He, W. Li, Z. Nie*, Y. Huang, Z.L. Liu, L.H. Nie, S.Z. Yao, Enzyme-Regulated Activation of DNAzyme: A Novel Strategy for Label-Free Colorimetric DNA Ligase Assay and Ligase-Based Biosensing, Chem. Eur. J.,2012, 18, 3992-3999.


26.Q.P. Shen, S.Y. Tang, W.H. Li, Z. Nie*, Z.L. Liu, Y. Huang, S.Z. Yao, Simple, A novel DNA-templated click chemistry strategy for fluorescent detection of copper(II) ions, Chem. Commun., 2012, 48, 281-283.


27.W. Li, Z. Nie*, K.Y. He, X.H. Xu, Y. Li, Y. Huang, S.Z. Yao, Simple, Rapid and label-free colorimetric assay for Zn2+ based on unmodified gold nanoparticles and specific Zn2+ binding peptide, Chem. Commun.,2011, 47, 4412-4414.


28.X.H. Xu, X. Liu, Z. Nie*, Y.L. Pan, M.L. Guo, S.Z. Yao, Label-free Fluorescent Detection of Protein Kinase Activity Based on the Aggregation Behavior of Unmodified Quantum Dots. Anal. Chem., 2011, 83, 52-59.


29.W. Li, Z.L. Liu, H. Lin, Z. Nie*, J.H. Chen*, X.H. Xu, S.Z. Yao, Label-Free Colorimetric Assay for Methyltransferase Activity Based on a Novel Methylation-Responsive DNAzyme Strategy. Anal. Chem., 2010, 82, 1935-1941.


30.Q.P. Shen, Z. Nie*, M.L. Guo, C.J. Zhong, B. Lin, W. Li, S.Z. Yao, Simple and rapid colorimetric sensing of enzymatic cleavage and oxidative damage of single-stranded DNA with unmodified gold nanoparticles as indicator. Chem. Commun.,2009, 919-931.


31.X.H. Xu, Z. Nie*, J.H. Chen*, Y.C. Fu, W. Li, Q.P. Shen, S.Z. Yao, DNA-based electrochemical strategy for label-free monitoring the activity and inhibition of protein kinase. Chem. Commun., 2009, 6946-6948.


32.C.Y. Deng, J.H. Chen*, Z. Nie*, M.D. Wang, X.C. Chu, X.L. Chen, X.L. Xiao, C.Y. Lei, S.Z. Yao, Impedimetric aptasensor with femtomolar sensitivity based on the enlargement of surface-charged gold nanoparticles. Anal. Chem.,2009, 81, 739-745.


33.C.Y. Deng, J.H. Chen*, L.H. Nie, Z. Nie*, S.Z. Yao, Sensitive Bifunctional Aptamer-Based Electrochemical Biosensor for Small Molecules and Protein. Anal. Chem., 2009, 81, 9972-9978.


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