朱海珍 Haizhen Zhu
教授，博士生导师  教育部新世纪优秀人才
Tel: 86-731-88821385
E-mail: Zhuhaizhen69@yahoo.com

研究方向：分子病毒学与免疫学、肿瘤分子生物学。
Research Interest: Concerns the interaction between virus and host, cancer cell signaling pathway

中文简介
2000年毕业于华中科技大学同济医学院，获得医学博士学位。2000-2005年在美国佛罗里达大学医学院病理学、免疫学和实验医学系从事博士后研究工作，2005-2009年任该系的Assistant Scientist。自2008年10月起任湖南大学教授，2009年9月起兼任湖南省肿瘤医院（现中南大学湘雅医学院附属肿瘤医院）教授。多年来一直从事病毒性肝炎和肝癌的发病机制、耐药机制以及药物与疫苗研发工作。主持承担国家科技重大专项、国家自然科学基金等科研项目，发表科研论文100余篇，参编英文学术专著1部，获得美国发明专利1项并授权，申请1项美国和欧盟发明专利，获国内发明专利6项。研究方向：病毒学与免疫学、肿瘤分子生物学。主要研究领域包括研究病毒与宿主的相互作用、肿瘤细胞信号传导及耐药机制、病毒及肿瘤细胞的免疫逃逸机制以及针对肝炎和肝癌生物治疗新技术新方法的研发。

Introduction
Dr. Zhu graduated from Tongji Medical College of Huazhong University of Science & Technology in 2000 and received his Doctor Degree in Medicine. Then he moved to USA and finished his postdoctoral research work at University of Florida College of Medicine in 2005. He became an Assistant Scientist in May 2005 and worked as a faculty member at Department of Pathology, Immunology and Laboratory Medicine at University of Florida College of Medicine from 2005 to 2009. Dr. Zhu has been a professor at Hunan University College of Biology since October 2008. He has also been working as an adjunct professor at Hunan Tumor Hospital (Affiliated Tumor Hospital of Xiangya Medical School of Central South University) since September 2009. He has published over 100 scientific research papers. H obtained grants from National Science & Technology Major Project and National Natural Science Foundation of China etc. He applied 6 patents including 2 international patents. One international patent was licensed. His research area includes virology, immunology and cancer molecular biology etc. His primary research interest concerns the interaction between virus and host, cancer cell signaling pathway, the mechanisms of drug resistance, the invasion mechanisms of virus and cancer cells and development of novel biological targeted therapy for hepatitis and liver cancer.

Selected Publications
1.Xue B, Yang D, Wang J, Xu Y, Wang X, Qin Y, Tian R, Chen S, Xie Q, Liu N, Zhu H. ISG12a restricts hepatitis C virus infection through the ubiquitination-dependent degradation pathway. Journal of Virology 2016; 90(15):6832-6845 (Spotlight in Journal of Virology 2016; 90(15):6611).
2.Yu R, Yang D, Lei S, Wang X, Meng X, Xue B, Zhu H. HMGB1 promotes hepatitis C virus replication by interaction with stem-loop 4 in the viral 5′ untranslated region. Journal of Virology 2016; 90(5):2332-2344.
3.Yang D, Zuo C, Wang X, Meng X, Xue B, Liu N, Yu R, Qin Y, Gao Y, Wang Q, Hu J, Wang L, Zhou Z, Liu B, Tan D, Guan Y, Zhu H. Complete replication of hepatitis B virus and hepatitis C virus in a newly developed hepatoma cell line. Proc Natl Acad Sci USA 2014; 111(13): E1264-E1273 (Highlight in PNAS 2014; 111(13):4735-4736) (Highlighted by Nature/SciBX in SciBX 7(11); doi:10.1038/scibx.2014.325).
4.Shi S, Yu X, Gao Y, Xue B, Wu X, Wang X, Yang D, Zhu H. Inhibition of hepatitis C virus production by aptamers against core protein. Journal of Virology 2014；88(4):1990-1999.
5.Liu N, Long Y, Liu B, Yang D, Li C, Chen T, Wang X, Liu C, Zhu H. ISG12a mediates cell response to Newcastle disease viral Infection. Virology 2014; 462-463:283-294.
6.Yu X, Gao Y, Xue B, Wang X, Yang D, Qin Y, Yu R, Liu N, Xu L, Fang X, Zhu H. Inhibition of hepatitis C virus infection by NS5A-specific aptamer. Antiviral Res 2014; 106:116-124.
7.Liu N, Zuo C, Wang X, Chen T, Yang D, Wang J, Zhu H. miR-942 decreases TRAIL-induced apoptosis through ISG12a downregulation and is regulated by AKT. Oncotarget 2014; 5:4959-4971.
8.Yang D, Meng X, Yu Q, Xu L, Long Y, Liu B, Fang X, Zhu H. Inhibition of hepatitis C virus infection by DNA aptamer against envelop protein. Antimicrobial Agents and Chemotherapy 2013; 57:4937-4944.
9.Zhu H, Dong H, Eksioglu E, Hemming A, Cao M, Crawford CM, Nelson DR, Liu C. Hepatitis C virus triggers apoptosis of a newly developed hepatoma cell line through antiviral defense system. Gastroenterology 2007; 133:1649-1659.
10.Zhu H, Zhao H, Collins CD, Eckerrode SE, Mcindoe RA, Crawford JM, Nelson DR, She JX and Liu C. Gene expression associated with interferon alfa antiviral activity in an HCV replicon cell line. Hepatology 2003; 37:1180-1188 (Editorial on Page 975-978).